The domestic and foreign macroeconomic operation in 2018 presents new changes and development trends. Economy in Pudong New District also shows a new development track. Based on relevant data，this paper makes judgment and analysis of economic operation characteristics and major macroeconomic indicators of Pudong New District in 2018. The year of 2019 is important for the development of 13th five-year plan. The quality of regional economy is directly related to the success of the 13th five-year plan. According to the comprehensive forecast，the economy of Pudong New District will maintain stable in 2019. Pudong New District should continue to promote development and opening-up with greater courage，intensify institutional breakthroughs in innovation，take deepening supply-side structural reform，constantly optimize the business environment，promote high-level reform and opening-up，and achieve high-quality economic development.