High-end manufacturing industry is the reflection of the high-end and advanced technology of the industrial value chain，is the practice of “Made in China in 2025” and other national strategies，is also the focus of global competition，the core of the transformation and development of Shanghai’s manufacturing industry，but also gradually become a symbol of Shanghai brand manufacturing. Shanghai high-end manufacturing industry must be integrated and think systematical from three dimensions of the status quo，the future and the overall situation（national and global），grasping the strategic opportunities such as deepening domestic reform，“Made in China in 2025” and Shanghai “The Science Innovation Centre”，in line with the new trend of global scientific and technological innovation，to form a high-end manufacturing development model driven by innovation and integrated development from the supply side reform，industrial development，talent，carrier and other aspects.