With the economy entering a new normal，Secretary-general Xi Jinping stressed in the report of the 19^th National Congress of the Communist Party of China on accelerating the development of advanced manufacturing，cultivating new growth points，forming new driving forces，supporting the optimization and upgrading of traditional industries and accelerating the development of modern service industry. Based on the economic zones，Fengxian district of Shanghai cultivates potential growth enterprises，promotes industrial concentration，takes the biological technological zone as the carrier，and focuses on the development of biological medicine and new energy industry. Fengxian vigorously promotes the beauty and health industry and create the “Oriental Beauty Valley”. Centering on the technological transformation and industrial upgrading of Shanghai industrial comprehensive development zone and Jianghai economic zone，Fengxian district promotes the transformation of traditional industries to strategic emerging industries and high-tech industries，and provides necessary support and supporting services for the development of advanced manufacturing industries within and outside the region. On April 18^th 2018，Shanghai Minhang Export Processing Zone transfers to the Comprehensive Free Trade Zone，which meets the needs of the transformation and upgrading of the manufacturing industry and the development of strategic emerging industries，and also provides good support and platform for fengxian district to become an important window and channel for international economic and trade. This paper takes Comprehensive Free Trade Zone as an example，to explore the transformation path of Shanghai Fengxian economic zone.