This study takes ten typical knowledge-based opinion leaders as the research objects，and conducts quantitative statistical analysis on the 765 microblog information it publishes to investigate the social responsibility performance of knowledge-based microblog opinion leaders. The research shows that there is room for improvement in the social responsibility performance of knowledge-based microblog opinion leaders. The average score of social responsibility evaluation scores is 2.52131 points （50.42% of the scores），which is just 1/2 of the full score. The knowledge-based microblog opinion leaders’ scores on “information production” are at the middle-to-upper level，but further optimization is needed for the performance of social responsibility in “cultural education”，“social supervision” and “coordination relationship”.