In order to understand the quality of life of middle-aged and elderly people with disability in China，this report constructed a quality of life index system from subjective and objective dimensions by using the data of CHARLS in 2015 and fuzzy set theory to measure the quality of life. The study found that the quality of life index of the middle-aged and elderly people with disability 0.411，just reached the intermediate level of quality of life；the quality of life index for moderate and severe disability were 0.382 and 0.358，at a low level of quality of life；more than 90% of middle-aged and elderly people with disability were in the low and intermediate level of quality of life；regardless of the average level or overall distribution，the quality of life of middle-aged and elderly people with disability was significantly lower than that of middle-aged and elderly people without disability；there was a large difference in quality of life between different groups.