As a group of the poorest，the most difficult to support and the highest rate of return to poverty，impoverished people with disabilities are the hardest “hard bones” in the fight against poverty. 2017 is the third year since the proposition of targeted poverty alleviation strategy. Through analyzing related policies and data，the report finds out that targeted poverty alleviation policies for people with disabilities have been perfected，more poverty alleviation programs have been put into practice，and poverty alleviation performance has been improved. At the same time，targeted poverty alleviation for people with disabilities still face many challenges，such as weak ability，heavy burdens on expenditure，more family containment，poor living environment for people with disabilities，single subject，regular content，inefficient means，poor implementation for anti-poverty work. Suggestions include refining and strengthening the process of targeted poverty alleviation for people with disabilities，building a multi governance pattern，and establishing a mechanism of internal drive and external guarantee.