The aim of Huawei’s proposal of establishing a project-centered project management system is to better support the coping ability and competiveness of enterprises in the face of complex business and market environments. Centering on project is not only the operation of business front-end project，but also includes the management support system that provides comprehensive support for the project. It is a complete structure of the front-end and back-end of business involving people，process，technology and strategy which is also known as the organization-level project management system in the industry. This paper comprehensively introduces construction practice and lesson learnt of Huawei’s project-centered project management system from the dimensions of organization，rules，process，IT，measurement and operation. This paper intends to inspire Chinese enterprises and therefore makes contribution to Chinese project management.