As a metropolitan city having started fast urbanization since the Reform and the Opening Up，the Guangzhou government has implemented series of resettlement policies for land-lost farmers. This artical presents the development process and policy performance of land-lost farmers resettlement policy in Guangzhou. The development process of land-lost farmers resettlement policy in Guangzhou performs four stages：Government Arrangement Period，Market Adjustment Period，Social Security Period and Urban-Rural Integration Period. In the context of the construction of national central city in Guangzhou，the artical also discusses four major challenges faced by the current land-lost farmers resettlement policies in Guangzhou. The challenges include：the problems of ‘Land for Security’ mode，the difficulty of re-employment for land-lost farmers in the context of industrial transformation，challenges of settlement communities governance and weaknesses of the current subsidiary resettlement methods. Finally，the artical gives the following suggestions，including improvements of pension system，the employment service，the community service and subsidiary methods for the land-lost farmers.