The health insurance payment system reform has a great impact on the drug market.The drugs covered by the health insurance drug catalogue accounts for about 60% of the domestic drug market scale.The health insurance has become the biggest buyer in the drug market.Establishing the goals of the health insurance payment system correctly is central to the reform.Effectively keeping some outstanding issues under control，such as unreasonably high prices of drugs，excessive medical treatment and drug ratios，is an important subject the reform faces.Focus the goal of the reform on the payment methods of the health insurance，establish three systems of “Global Budget，Diseases Related to Groups，Health Insurance Payment Standard”，and shift from the previous post payment to advance payment.Actually，it's a system of payment partly in kind and partly in cash.With this payment method，the management of hospitals，doctors' diagnosis and treatment，the procurement of drugs，the categorization of drug prices，pharmaceutical enterprises' marketing，and the government's supervision will also change accordingly.