The Changjiang Middle Reaches Megalopolis，one of the three major urban agglomerations in the Yangtze River Economic Belt，was treated as the research object，and the urbanization efficiency of the urban agglomeration were measured and analyzed. The three-stage DEA method was used to compare the Changjiang Middle Reaches Megalopolis of the urban agglomeration between 2005 and 2015. The urbanization efficiency of each city was measured，and the results of the model was analyzed. The evolution law and characteristics of urban agglomeration were analyzed through horizontal and vertical comparison. Finally，the corresponding suggestions were proposed according to the urbanization efficiency development，change characteristics and conclusions of the Changjiang Middle Reaches Megalopolis.