In recent years，Jiangsu-based enterprises have accelerated their“going global”pace，along with the implementation of the Belt and Road Initiative and the development trajectory of enterprises.The going-global enterprises agglomerate and integrate global high-end resources，aiming at building transnational enterprises with global competitiveness.During the process of“going global”，considerable experience has been accumulated，new characteristics and highlights have been presented，and quality and benefits have been significantly boosted. Meanwhile，the enterprises still encounter many difficulties and challenges，especially against the background of the growing de-globalization trend，the political，economic and cultural risks and uncertainties increase dramatically. In face of such circumstances，government，enterprises and society should join hands to introduce countermeasures.