Suzhou， Hangzhou， Jiangning developed into the most developed area of publishing industry in the early Qing Dynasty. Different from the publishing and publishing of books in Jianning， Fujian Province， in the late Ming Dynasty， the publishing situation of literati and bookshop owners was gradually formed in these areas in the early Qing Dynasty， especially in the field of popular culture， because of the literati's participation in publishing activities. The standard of publications has been greatly improved and the printing of publications has become more sophisticated. Among them， Li Yu's publishing activities in Jiangsu in the early Qing Dynasty are the most representative， and the analysis of this case is not without inspiration in our book publishing industry today.